Trefoil factors — new markers of gastrointestinal mucosal barrier

Gastrointestinal mucosal regeneration: role of growth factors.

Growth factors and their receptors play important roles in cell proliferation, migration, tissue injury repair and ulcer healing. In gastric mucosa, transforming growth factor alpha (TGF-alpha) and epidermal growth factor (EGF) by activating their common receptor, control cell proliferation. TGF-alpha predominantly plays this role under normal conditions and after acute injury, while EGF exerts...

Childhood gastrointestinal dysfunction and protection mechanism of intestinal mucosal barrier

Childhood gastrointestinal dysfunction has been recognized as the triggering elements of multiple organ failure. The causes of gastrointestinal dysfunction include: injury of intestinal barrier, release of inflammatory mediators, translocation of intestinal bacteria, gastrointestinal mucosal ischemia and anoxia injury caused by abnormal intestinal blood flow perfusion, and apoptosis of gastroin...

Differential expression of mucosal trefoil factors and mucins in pediatric inflammatory bowel diseases

In the intestinal mucosa trefoil factors (TFF) and mucins (Muc) - primarily produced by goblet cells - are thought to play a major role in providing barrier function during infection and inflammation. To investigate their role in pediatric Crohn's disease (CD) and ulcerative colitis (UC) we obtained mucosal biopsies of children with CD, UC and healthy controls and analyzed genetic expression. L...

Monitoring Gastrointestinal Mucosal Perfusion

Biliary Mucosal Barrier and Microbiome

BACKGROUND The biliary system is in continuous contact with the complex microbiota of the intestine. Microbial products have recently been proposed as potential triggers for biliary diseases. METHODS The aim of this review is to provide a summary of the current knowledge regarding the role of the biliary and intestinal microbiome in biliary inflammatory diseases. RESULTS Previously, it was ...